Guido Cavaletti

Guido Cavaletti

University Surgery and Translational Medicine - UNIMIB
Laboratories Experimental Neurology Unit
Research fields

Research topics
Chemotherapy-induced peripheral neurotoxicity:
researchers working at ENU have originally developed most of the available animal models of CIPN (cisplatin, carboplatin, oxaliplatin, paclitaxel, docetaxel, bortezomib, epothilones, …) and effective in vitro screening models are available
Adult and embryonic cellular systems are used to investigate on CIPN pathogenesis and to test neuroprotective drugs
ENU is the leading partner of the international collaborative CI-PeriNoms study group involving more than 20 centers in Europe and US and dedicated to the assessment of CIPN in patients undergoing neurotoxic chemotherapy

Multiple sclerosis:
At the ENU innovative treatments for multiple sclerosis are tested in the EAE model, in parallel to pathogenetic studies in vivo, ex vivo and in vitro
Experimental studies on possible disease biomarkers are performed in collaboration with the Neuroimmunology Center at the S. Gerardo Hospital in Monza

Innovative drug delivery:
The use of different types of nanoparticles is tested for their toxicity and effectiveness in order to improve drug delivery in cellular systems and in vivo in oncology, neuroimmunology and CIPN models

Restorative medicine:
Encapsulated pancreatic islets are tested as a therapeutic option in experimental diabetes
Mesenchimal stem cells are tested for their capacity to modulate the immune response in EAE and experimental diabetes and as suppotive agents in transplant experimental medicine

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