4 April 2017 , 13:00
Edificio U8 – Via Cadore 48, Monza

Mitotic entry is a dramatic transition, during which every cellular compartment is dramatically rearranged within minutes to prepare the cell for division. We do know the main players of this transition, but we have very little understanding, how they work together to bring about this highly complex cellular switch. We have been using novel genetic approaches in combination with mathematical modelling to develop a systems wide analysis of mitotic entry in human cell lines. Using these tools we have investigated how cells employ two partially independent feedback systems to bring about a robust, irreversible and well orchestrated transition from G2 to M-phase, and have identified the individual contributions of the key players Cyclin A and B during mitotic entry.